ARES Archived Posts
Pam Tolomeo - Winner of the DBEI Community All Star Award.
Pam Tolomeo received the Community All Star Awards at the DBEI CCEB Milestone Ceremony. A well deserved award for a selfless and always helpful member of the ARES team! Pam always goes above and beyond and makes time for others!
Naledi Mannathoko, PhD, Accepted Abstract at SHEA in Seattle, Washington, April 12 - 14 2023
Poster: “Risk Factors for Colonization with Extended-Spectrum Cephalosporin-Resistant Enterobacterales(ESCrE) in Hospitalized Patients in Botswana: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study"
Authors: Naledi Mannathoko, PhD; Mosepele Mospele, MD, MSc; Robert Gross, MD, MSCE; Rachel Smith, MD; Ashley Styczynski, MD, MPH; Leigh Cressman, MA; Melissa Richard-Greenblatt, PhD; Laurel Glaser, MD, PhD; Kevin Alby, PhD; Anne Jaskowiak-Barr, MS, BSW; Kgotlaetsile Sewawa;Laura Cowden, MS; Dimpho Otukile; Giacomo Paganotti, PhD; Margaret Mokomane, PhD; Warren Bilker, PhD; Ebbing Lautenbach, MD, MPH
Matt Ziegler, MD, MSCE presenting at SHEA in Seattle, Washington, April 12 - 14 2023
Talk: “Role of the hospital environment in healthcare-associated infections due to MDR Gram-negative bacteria” -Wednesday 1:30-2:30PM
Swarn Arya, DO presenting at SHEA in Seattle, Washington, April 12 - 14 2023
Poster: “Antibiotic Practice & Stewardship in the Management of Neutropenic Fever: A Survey of US Institutions” -Wednesday 12-1:30PM
Kevin Bouiller presenting at ECCMID 2023 in Copenhagen, Denmark on 15 - 18 April 2023
Factors associated with foreign body infection in patients with MRSA bacteremia presented at ECCMID
Kevin Bouiller, PhD, Natasia Jacko, MPH; and Michael David, MD, PhD
Identifying and Studying Emerging Infections: A Faculty Panel Discussion
Dr. Kelly lead a discussion with panelists Frederic Bushman, PhD; Ricardo Castillo, PhD, DVM, MSPH; Stuart Isaacs, MD; Julia Szymczak, PhD; Susan Weiss, PhD; and Matthew Ziegler, MD, MSCE. Experts discussed the current outbreak of monkey pox and other emerging infections, learnings from COVID19, and how we can be best prepared for emerging infections and pandemics in the future at Penn Medicine.
Archived Publications
Han JH, Goldstein EJ, Wise J, Bilker WB, Tolomeo P, Lautenbach E. Epidemiology of carbapenem-resistant Klebsiella pneumoniae in a network of long-term acute care hospitals. Clinical Infectious Diseases. 2017 Apr 1; 64(7):839-844. PMCID: PMC5399931.
Han JH, Garrigan C, Johnston B, Nachamkin I, Clabots C, Wilker WB, Santana E, Tolomeo P, Maslow J, Myers J, Carson L, Lautenbach E, Johnson JR, for the CDC Prevention Epicenters Program. Epidemiology and characteristics of Escherichia coli sequence type 131 (ST131) from long-term care facility residents colonized intestinally with fluoroquinolone-resistant Escherichia coli. Diagnostic Microbiology and Infectious Diseases. 2017 March; 87(3):275-80. PMCID: PMC5292283.
Rattanaumpawan P, Nachamkin I, Bilker WB, Roy JA, Metlay JP, Zaoutis TE, Lautenbach E, for the CDC Prevention Epicenters Program. High fluoroquinolone MIC is associated with fluoroquinolone treatment failure in urinary tract infections caused by fluoroquinolone susceptible Escherichia coli. Annals of Clinical Microbiology and Antimicrobials. 2017 Apr 8; 16(1):25. PMCID: PMC5385084.
Cluzet VC, Gerber JS, Nachamkin I, Coffin SE, Davis MF, Julian KG, Zaoutis TE, Metlay JP, Linkin DR, Tolomeo P, Wise JA, Bilker WB, Hu B, Lautenbach E, for the CDC Prevention Epicenters Program. Factors associated with persistent colonisation with methicillin-resistant Staphylococcus aureus. Epidemiology and Infection. 2017 May; 145(7):1409-1417.
Downes KJ, Weiss SL, Gerber JS, Klieger SB, Fitzgerald JC, Balamuth F, Kubis SE, Tolomeo P, Bilker WB, Han X, Nachamkin I, Garrigan C, Han JH, Lautenbach E, Coffin SE, Centers for Disease Control and Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Journal of the Pediatric Infectious Diseases Society. 2017 Jun 1;6(2):134-141. doi: 10.1093/jpids/piw023. PMCID: PMC5907860.
Kerlin MP, Trick WE, Anderson DJ, Babcock HM, Lautenbach E, Gueret R, Klompas M. Interrater Reliability of Surveillance for Ventilator-Associated Events and Pneumonia. Infection Control and Hospital Epidemiology. 2017 February; 38(2):172-178.
Pegues DA, Han J, Gilmar C, McDonnell B, Gaynes S. Impact of Ultraviolet Germicidal Irradiation for No-Touch Terminal Room Disinfection on Clostridium difficile Infection Incidence Among Hematology-Oncology Patients. Infection Control and Hospital Epidemiology 2017 Jan;38(1):39-44. doi: 10.1017/ice.2016.222. Epub 2016 Oct 6.
Vaughan A, Ross R, Gilman M, Satchell L, Ditaranto S, Reilly A, Kersun L, Shanahan A, Coffin S, Sammons JS: Mucosal Barrier Injury Central Line Associated Bloodstream Infections: what is the impact of standard prevention bundles? Infection Control and Hospital Epidemiology 38(11): 1385-1387, November 2017.
Anesi J, Lautenbach E, Nachamkin I, Garrigan C, Bilker WB, Wheeler M, Tolomeo P, Han JH. Clinical and molecular characterization of community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae. Infection Control and Hospital Epidemiology. 2016 December; 37(12):1433-1439. PMCID: PMC5440186.
Cluzet VC, Gerber JS, Metlay JP, Nachamkin I, Zaoutis TE, Julian KG, Linkin DR, Coffin SE, Margolis DJ, Hollander JE, Bilker WB, Han X, Mistry RD, Gavin LJ, Tolomeo P, Wise JA, Wheeler MK, Hu B, Fishman NO, Royer D, Lautenbach E, for the CDC Prevention Epicenters Program. The Effect of Total Household Decolonization on Clearance of Colonization with Methicillin-Resistant Staphylococcus aureus. Infection Control and Hospital Epidemiology. 2016; 37(10):1226-1233.
Garrigan C, Han J, Tolomeo P, Heaton-Johnson KA, Master SR, Lautenbach E, Nachamkin I. Evaluation of a research use only luminex based assay for measurement of procalcitonin in serum samples. American Journal of Translational Research. 2016; 8(10): 4362-4369. PMCID: PMC5095329
Kelly BJ, Lautenbach E, Nachamkin I, Coffin SE, Gerber JS, Fuchs BD, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Han JH, Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis. Diagnostic Microbiology and Infectious Diseases 2016 May;85(1):109-15. doi: 10.1016/j.diagmicrobio.2016.01.003. Epub 2016 Jan 8. PMCID: PMC4841711
Mills JP, Talati NJ, Alby K, Han JH. The Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Colonization and Infection among Long-Term Acute Care Hospital Residents. Infection Control and Hospital Epidemiology. 2016 Jan;37(1):55-60. doi: 10.1017/ice.2015.254. Epub 2015 Oct 12. PMCID: PMC4815918,
Davis MF, Hu B, Carroll KC, Bilker WB, Tolomeo P, Cluzet VC, Baron P, Ferguson JM, Morris DO, Rankin SC, Lautenbach E, Nachamkin I. Comparison of culture-based methods for identification of colonization with methicillin-resistant and methicillin-susceptiblte Staphylococcus aureus in the context of colonization. Journal of Clinical Microbiology. 2016 Jul; 54(7): 1907-1911. PMCID: PMC4922128.
Cluzet VC, Gerber JS, Nachamkin I, Metlay JP, Zaoutis TE, Davis MF, Julian KG, Royer D, Linkin DR, Coffin SE, Margolis DJ, Hollander JE, Mistry RD, Gavin LJ, Tolomeo P, Wise JA, Wheeler MK, Bilker WB, Han X, Hu B, Fishman NO, Lautenbach E. Duration of Colonization and Determinants of Earlier Clearance of Colonization With Methicillin-Resistant Staphylococcus aureus. Clinical Infectious Diseases; 2015 May 15; 60(10): 1489-1496.PMCID: PMC4490328.
Cluzet VC, Lautenbach E, Nachamkin I, Cary MS, Fishman NO, Shih N, Morales KH, Linkin DR. Risk factors for gyrA and parC mutations in Pseudomonas aeruginosa. Infection Control and Hospital Epidemiology. 2015 Apr; 36(4):387-393.
Hamilton KW, Gerber JS, Moehring R, Anderson DJ, Calderwood MS, Han JH, Mehta JM, Pollack LA, Zaoutis T, Srinivasan A, Camins BC, Schwartz DN, Lautenbach E, for the CDC Prevention Epicenters Program. Point-of-Prescription Interventions to Improve Antimicrobial Stewardship. Clinical Infectious Diseases. 2015 Apr 15; 60(8):1252-1258. PMCID: PMC4415059.
Han JH, Nachamkin I, Coffin SE, Gerber JS, Fuchs B, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Lautenbach E, for the CDC Prevention Epicenters Program. Use of a combination biomarker algorithm to identify medical intensive care unit patients with suspected sepsis at very low likelihood of bacterial infection. Antimicrobial Agents and Chemotherapy. 2015 Oct; 59(10): 6494-6500. PMCID: PMC4576082.
Han JH, Sullivan N, Leas BF, Pegues DA, Kaczmarek JL, Umscheid CA. Cleaning hospital room surfaces to prevent healthcare-associated infections. Annals of Internal Medicine. 2015 Oct 20; 163(8):598-607. PMCID: PMC4812669.
Jou JJ, Ebrahim J, Schofer F, Hamilton KW, Stern J, Han JH, for the CDC Prevention Epicenters Program. Environmental transmission of Clostridium difficile: association between hospital room square footage and C. difficile infection. Infection Control and Hospital Epidemiology. 2015 May; 36(5):564-568. PMCID: PMC4402219.
Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infection Control and Hospital Epidemiology 2016 Apr;37(4):483-5. doi: 10.1017/ice.2015.307. Epub 2015 Dec 16.
Manning S, Lautenbach E, Tolomeo P, Han JH. Risk factors for infection with Escherichia coli in nursing home residents colonized with fluoroquinolone-resistant E. coli. Infection Control and Hospital Epidemiology. 2015 May; 36(5):575-577. PMCID: PMC4402708.
Misic AM, Davis MF, Tyldsley AS, Hodkinson BP, Tolomeo P, Hu B, Nachamkin I, Lautenbach E, Morris DO, Grice EA. The shared microbiota of humans and companion animals as evaluated from Staphylococcus carriage sites. Microbiome 2015; 3(1):2. PMCID: PMC4335418.
Rattanaumpawan P, Nachamkin I, Metlay J, Zaoutis T, Bilker W, Roy J, Lautenbach E, and for the CDC Prevention Epicenters Program. Risk factors for ambulatory urinary tract infections caused by high MIC-fluoroquinolone susceptible E. coli in women: results from a large case-control study. Journal of Antimicrobial Chemotherapy. 2015 May; 70(5): 1547:1551. PMCID: PMC4398470.
Richardson DM, Medvedeva EL, Roberts CB, Linkin DR, for the CDC Prevention Epicenters Program. Comparative Effectiveness of High-Dose versus Standard-Dose Influenza Vaccination in Community-Dwelling Veterans. Clinical Infectious Diseases. 2015 Jul 15; 61(2): 171-176.
Szymczak JE, Smathers S, Hoegg C, Klieger S, Coffin SE, Sammons JS. Reasons Why Physicians and Advanced Practice Clinicians Work While Sick: A Mixed-Methods Analysis. JAMA Pediatrics. 2015 Sep; 169(9): 815-821.
Caroff DA, Edelstein PH, Hamilton K, Pegues DA, for the CDC Prevention Epicenters Program. The Bristol stool scale and its relationship to Clostridium difficile infection. Journal of Clinical Microbiology. 2014 Sep; 52(9):3437-3439. PMCID: PMC4313178.
Caroff DA, Norris AH, Keller S, Vinnard C, Zeitler KE, Lukaszewicz J, Zborowski KA, Linkin DR, for the CDC Prevention Epicenters Program. Catheter-Salvage in Home Infusion Patients with Central Line-Associated Bloodstream Infection. American Journal of Infection Control. 2014 Dec; 42(12): 1331-1333. PMCID: PMC4255141.
Han JH, Johnston B, Nachamkin I, Tolomeo P, Bilker WB, Mao X, Clabots C, Lautenbach E, Johnson JR, for the CDC Prevention Epicenters Program. Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 (ST131) among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E. coli. Antimicrobial Agents and Chemotherapy. 2014 Nov; 58(11): 7003-7006. PMCID: PMC4249391.
Han JH, Maslow J, Han X, Xie SX, Tolomeo P, Santana E, Carson L, Lautenbach E. Risk factors for the development of gastrointestinal colonization with fluoroquinolone-resistant Escherichia coli in residents of long-term care facilities. Journal of Infectious Diseases. 2014 Feb; 209(3):420-425. PMCID: PMC3883173.
Mehta JM, Haynes K, Wileyto EP, Gerber JS, Timko DR, Morgan SC, Binkley S, Fishman NO, Lautenbach E, Zaoutis TE, for the CDC Prevention Epicenters Program. Comparison of Prior Authorization and Prospective Audit with Feedback for Antimicrobial Stewardship. Infection Control and Hospital Epidemiology. 2014 Sep; 35(9):1092-1099. PMCID: PMC4198070.
Szymczak JE, Feemster KA, Zaoutis TE, Gerber JS. Pediatrician Perceptions of an Outpatient Antimicrobial Stewardship Intervention. Infection Control and Hospital Epidemiology. 2014 Oct; 35(S3): S69-S78.
Cheema S, Vinnard C, Foster-Chang S, Linkin DR. A Time-Off Incentive Was Not Associated with Influenza Vaccination Acceptance among Healthcare Workers. Influenza Research and Treatment. 2013; Article ID: 209491, 4 pages. http://dx.doi.org/10.1155/2013/209491.
Greenblatt RM, Han JH, Nachamkin I, Tolomeo P, Lautenbach E. Defining Relatedness in Studies of Transmission of Antimicrobial-Resistant Organisms: Variability in Definitions across Studies and Impact of Different Approaches on Study Conclusions. Infection Control and Hospital Epidemiology. 2013 Jan; 34(1): 40-48. PMCID: PMC3983273.
Han JH, Edelstein PH, Bilker WB, Lautenbach E. The Effect of Staphylococcal Cassette Chromosome mec (SCCmec) Type on Clinical Outcomes in Methicillin-Resistant Staphylococcus aureus Bacteremia. Journal of Infection. 2013 Jan; 66(1):41-47. PMCID: PMC3518704.
Han JH, Nachamkin I, Tolomeo P, Mao X, Bilker WB, Lautenbach E. Temporal Changes in Resistance Mechanisms in Colonizing Escherichia coli Isolates with Reduced Susceptibility to Fluoroquinolones. Diagnostic Microbiology and Infectious Diseases. 2013 Aug; 76(4):491-496. PMCID: PMC3725193.
Han JH, Bilker WB, Nachamkin I, Tolomeo P, Mao X, Fishman NO, Lautenbach E. Impact of Antibiotic Use During Hospitalization on the Development of Gastrointestinal Colonization with Escherichia coli with Reduced Fluoroquinolone Susceptibility. Infection Control and Hospital Epidemiology. 2013 Oct; 34(10):1070-1076. PMCID: PMC3979459.
Han JH, Bilker WB, Nachamkin I, Zaoutis TE, Coffin SE, Linkin DR, Hu B, Tolomeo P, Fishman NO, Lautenbach E. The Effect of a Hospital-Wide Urine Culture Screening Intervention on the Incidence of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Species. Infection Control and Hospital Epidemiology. 2013 Nov; 34(11): 1160-1166. PMCID: PMC3981746.
Keller SC, Linkin DR, Fishman NO, Lautenbach E. Variations in Identification of Healthcare-Associated Infections. Infection Control and Hospital Epidemiology. 2013 Jul; 34(7):678-686. PMCID: PMC3981741.
KliegerSB, Potter-Bynoe G, Quach C, Sandora TJ, Coffin SE. Beyond the Bundle: a survey of CLABSI prevention practices used in U.S. and Canadian pediatric hospitals. Infection Control and Hospital Epidemiology. 2013 Nov; 34(11):1208-1210.
Linkin DR, Fishman NO, Shea JA, Yang W, Cary MS, Lautenbach E. Public Reporting of Hospital Acquired Infections is Not Associated with Improved Processes or Outcomes. Infection Control and Hospital Epidemiology. 2013 Aug; 34(8):844-846. PMCID: PMC3979462.
Sammons JS, Localio R, Xiao R, Coffin SE, Zaoutis T. Clostridium difficile Infection is associated with Increased Risk of Death and Prolonged Hospitalization in Children. Clinical Infectious Diseases. 2013 Jul; 57(1):1-8. PMCID: PMC3669523.
Vinnard C, Gopal A, Linkin DR, Maslow J. Isoniazid Toxicity Among an Older Veteran Population: A Retrospective Cohort Study. Tuberculosis Research and Treatment. 2013:Article ID: 549473, 4 pages. http://dx.doi.org/10.1155/2013/549473. PMCID: PMC3556878.
Han JH, Edelstein PH, Lautenbach E. Reduced Vancomycin Susceptibility and Staphylococcal Cassette Chromosome mec (SCCmec) Type Distribution in Methicillin-Resistant Staphylococcus aureus Bacteremia. Journal of Antimicrobial Chemotherapy. 2012 Oct; 67(10):2346-2349. PMCID: PMC3444231.
Han JH, Kasahara K, Edelstein PH, Bilker WB, Lautenbach E. Risk factors for infection or colonization with CTX-M extended-spectrum β-lactamase (ESBL)-positive Escherichia coli. Antimicrobial Agents and Chemotherapy. 2012 Nov; 56(11):5575-5580. PMCID: PMC3486585.
Han JH, Nachamkin I, Tolomeo P, Mao X, Bilker WB, Lautenbach. E. Risk Factors for Efflux Pump Overexpression in Fluoroquinolone-Resistant Escherichia coli. Journal of Infectious Diseases. 2012 Nov 15; 206(10):1597-1603. PMCID: PMC3475638.
Han JH, Nachamkin I, Zaoutis TE, Coffin SE, Linkin DR, Fishman NO, Weiner MG, Hu B, Tolomeo P, Lautenbach E. Risk factors for gastrointestinal tract colonization with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella species in hospitalized patients. Infection Control and Hospital Epidemiology. 2012 Dec; 33(12):1242-1245. PMCID: PMC3983276.