keithhamilton

Keith Hamilton, MD, FACP, FSHEA is an Associate Professor of Clinical Medicine in the Division of Infectious Diseases at the Perelman School of Medicine at the University of Pennsylvania and the Director of Antimicrobial Stewardship, Co-Chair of the Antibiotic Subcommittee of the Pharmacy and Therapeutics Committee, Vice-Chair of the Pharmacy and Therapeutics Committee, and Associate Healthcare Epidemiologist at the Hospital of the University of Pennsylvania. His main research interests are in the area of antibiotic stewardship, specifically in developing innovative methods to increase efficiency and success of interventions designed to promote judicious antibiotic prescribing. One specific interest is using technology to augment antibiotic stewardship programs. For instance, he has used large data sets and predictive models to inform real-time personalized antibiotic prescribing practices. In addition, he has developed automated systems to identify potential stewardship interventions using electronic alerts, designed clinical decision support systems to guide appropriate antibiotic prescribing, and created informative electronic metrics for reporting and identifying interventions.

Dr. Hamilton is also interested in less high-technology approaches to antibiotic stewardship. For example, he has investigated the impact of antibiotic allergies on antibiotic prescribing as well as developing novel interventions to reconcile and de-label antibiotic allergies through clinical evaluation and penicillin skin testing. In addition, he has sought to understand and describe the ethical and legal implications of antibiotic stewardship in order to provide practical guidance to antibiotic stewardship programs to address opportunities and challenges in these areas. He also has interest in expanding the implementation of stewardship programs to a variety of different healthcare settings and patient populations, including ambulatory practices and transitions of care. He has performed multiple research projects in these settings, including to improve antibiotic prescribing for respiratory tract diagnoses in primary care practices and to improve outcomes in patients discharged from the inpatient setting on outpatient parenteral antibiotic therapy. Finally, Dr. Hamilton has expertise in medical education, serving as Director of the Internal Medicine Clerkship and Director of Undergraduate Medical Education for the Department of Medicine. He has applied this expertise to develop unique approaches to education about antibiotic stewardship and antibiotic prescribing.