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Microbiome Research, Transmission Studies & Environmental Studies

Microbiome Research, Transmission Studies & Environmental Studies

FACE MDRO: Large Optional Collaborative Project: Fecal Microbiota Transplantation to Address Colonization and Environmental Contamination with Multidrug-Resistant Organisms

PI: Brendan Kelly, MD

Study Dates: 06/01/21 – 05/31/26

Funding Source: CDC

Area of Focus:

Healthcare-associated Infections; Microbiome Research; C. Diff; 


Specific Aims: The projects proposed in this application seek to build on the strong foundation established by core and collaborative projects conducted by the Penn-CHOP investigators over the past 5 years.

MERLIN: Clinical and Molecular Determinants of ESBL Transmission in the Community

PI: Ebbing Lautenbach, MD, MPH, MSCE

Study Dates: 7/1/20-8/31/22

Funding Source: CDC

Area of Focus:

ESBLS, transmission


Specific Aims: This project will answer key questions about the clinical and molecular determinants of transmission of community-onset ESBLs with a specific focus on transmission within the household.

Microbiome Sampling in Pediatric Post-Acute Care to Understand Multidrug-resistant Organism Risk, Antibiotic Effect, and Ventilator-associated Infection

PI: Ebb Lautenbach, MD, MSCE, MPH

 

Project Lead: Katie Chiotos

 

Study Dates: 6/1/2021-5/31/2026

 

Funding Source: Centers for Disease Control and Prevention

 

Area of Focus:

Respiratory microbiome, ventilator-associated pneumonia diagnostics, multidrug resistant organisms

 

Specific Aims:

Aim 1: To determine the longitudinal changes in LRT and GI alpha diversity attributable to antibiotic class exposure.

Aim 2: To determine the impact of LRT and GI dysbiosis on diagnosis of LRTI.

Aim 3: To determine the association between LRT and GI dysbiosis and MDRO and/or other bacterial colonization.

NEXUS: Non-residential exposures to multidrug-resistant organisms

PI: Matthew Ziegler, MD, MSCE

 

Study Dates: 06/01/23 – 12/31/25

 

Funding Source: CDC Prevention Epicenter Program

 

Area of Focus:

Environmental transmission of pathogens; healthcare-associated infection

 

Specific Aims:

This project aims to define high-touch objects and to determine effectiveness of cleaning within inpatient NEXUS areas including dialysis, radiology, and physical and occupational therapy

Southeastern Pennsylvania Adult and Pediatric Prevention Epicenter Network

PI: Ebbing Lautenbach, MD, MPH, MSCE

Study Dates: 06/01/21 – 05/31/26

Funding Source: CDC

Area of Focus:

Healthcare-associated Infections; Microbiome Research; C. Diff; 


Specific Aims: The projects proposed in this application seek to build on the strong foundation established by core and collaborative projects conducted by the Penn-CHOP investigators over the past 5 years.